June 8, 2021

Where is Alprostadil used?

Alprostadil is an FDA-approved medication recommended for use in men with erectile dysfunction. This medicine helps the blood flow into the penis to achieve and maintain an erection. Alprostadil is identical to a naturally occurring substance found in the body that helps keep the blood vessels open. This prescription is supplied as a sterile solution for intravascular infusion.


How does Alprostadil work?

Alprostadil is a type of medicine called prostaglandin which is similar to a naturally occurring chemical called prostaglandin E1. Prostaglandin E1 is assumed to cause certain types of blood vessels to expand by relaxing the thin layer of muscle in the blood vessel wall. An erection is made through a complex chain of events. It includes signals from the nervous system and the discharge of active chemicals within the tissues of the penis. This causes blood vessels entering the penis to widen which allows more blood to enter. Other blood vessels leave the penis to tighten and stopping the blood from entering the penis.

Prostaglandin E1 plays a significant role in this course once administered right into the penis. It will eventually cause the penis to erect by increasing the blood flow into its tissues.


How is Alprostadil taken?

The dosage will depend on your medical condition, age, weight, and response to the treatment. Follow the instructions of your doctor very carefully. You should not take the medication more or less than it is prescribed. Let your doctor know if your condition does not improve or if it gets worse.

Alprostadil is used by inserting the suppository into the penis or as directed by your doctor. Your doctor may direct you to start at a low dose and gradually increase it. You should not use more than 2 doses in 24 hours.

This medication usually starts to work in about 5-10 minutes. Intercourse must be attempted within 10 to 30 minutes after having this medication. An erection might last after ejaculation but should not be firm or last longer than an hour.


What are the precautions in taking Alprostadil?

  • Be sure to tell your doctor if you are taking any other medications such as vitamins or herbal supplements.
  • This may not be recommended for use if you have a history of an allergic reaction with this medicine. Inform your doctor if you have any other allergies. Alprostadil may contain certain ingredients that cause an allergic reaction.
  • Call your doctor right away if your erection lasts longer than 4 hours.
  • This is not for use in women or children.
  • This is not recommended for use in men who have an implant in their penis and with a physical abnormality of the penis.
  • Tell your doctor if you have a medical history of penis conditions, cavernosal fibrosis, blood system cancers, or heart disease.
  • This drug may make you drowsy or dizzy. Do not use any machinery or do anything that needs your alertness until you can do it safely.
  • Alcohol can make you dizzier. Avoid alcoholic beverages while having this medication.
  • Use this drug with caution in men with blood clotting disorders, heart disease, lung disease, small temporary strokes, or a history of psychiatric illness.

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