May 4, 2021

Where is Alogliptin used?

Alogliptin is a tablet medication used to control blood sugar levels in people with type 2 diabetes mellitus. A well-controlled blood sugar level helps prevent:

  • Blindness
  • Nerve problems
  • Kidney damage
  • Loss of limbs
  • Sexual function problems
  • Heart attack
  • Stroke

This drug belongs in the group called DPP-4 inhibitors. This prescription is usually used when your blood sugar cannot be sufficiently controlled by exercise, diet, or other antidiabetic medicines.


How does Alogliptin work?

Alogliptin works by increasing the amount of two incretin hormones. These hormones are glucose-dependent insulinotropic peptide (GIP) and glucagon-like peptide-1 (GLP-1) and are usually made naturally by the body in response to food consumption. The task of GIP and GLP-1 is to help control blood sugar levels. In addition, these hormones have four main actions on how it helps control blood sugar:

  • Firstly, these hormones stimulate the pancreas to create insulin in response to increasing levels of glucose in the blood. Insulin is the leading hormone accountable for controlling sugar levels in the blood. It causes cells in the body to eliminate sugar from the blood.
  • GLP-1 lessens the fabrication of glucagon which is a hormone that usually increases glucose production by the liver.
  • GIP and GLP-1 decrease the rate at which food passes from the stomach into the intestines. It slows down the absorption of glucose from the gut into the bloodstream.
  • Finally, they act on the brain to cause a feeling of fullness that decreases further food intake.

GIP and GLP-1 are usually broken down by dipeptidyl peptidase 4. This medication binds to this enzyme and stops it from breaking down the GIP and GLP-1. This raises the levels of these hormones in the body as well as their effects on controlling blood sugar.


How is Alogliptin taken?

The recommended dosage for this medication will depend on your condition and response.

  • The usual dose for this medicine is one 25 mg tablet taken once a day by mouth.
  • Swallow the tablet as a whole with a glass of water.
  • Each medicine can be taken with or without a meal/food.
  • Take each dose at the same time each day. It will help you remember to take it regularly.

Follow your doctor’s prescription very carefully. To avoid complications, do not double the dose. If you missed a dose, call your doctor or healthcare provider for instructions. Do not take more or less than the recommended dosage.


What are the precautions in using Alogliptin?

  • Before taking this prescription, tell your doctor if you are allergic to it. This drug may contain an ingredient that causes an allergic reaction.
  • Consult your doctor if you are a pregnant or breastfeeding woman.
  • Tell to your doctor if you have any medical history or current medications including vitamins or herbal supplements.
  • Do not skip meals if you are taking this medicine.
  • This may make you feel dizzy. Avoid driving or do any activity that needs your alertness.
  • This medicine should not be used for the treatment of type-I diabetes. It is where your body does not make enough insulin.
  • Call for medical assistance right away if you have stomach pain, or feeling sick along with nausea and vomiting.

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