March 30, 2021

Where is Abemaciclib used?

Abemaciclib is a prescription used for the treatment of certain types of cancer. For the treatment of postmenopausal women, it is given in combination with an aromatase inhibitor as initial endocrine-based therapy. The following are the types of breast cancer:

  • Hormone Receptor-Positive Breast Cancer
  • HER2-Positive Breast Cancer
  • Triple-Negative Breast Cancer

This medicine is considered an anti-cancer or antineoplastic drug that belongs to the kinase inhibitors group of drugs. This tablet is also classified as a Cyclin-Dependent kinase inhibitor. In the year 2017, Abemaciclib has already been approved by the Food and Drug Administration (FDA).


How does Abemaciclib work?

Abemaciclib is a changeable small-molecule Cyclin-dependent kinase inhibitor. It blocks Cyclin-dependent kinase (CDK) 4 and CDK 6 which are proteins in cells. It ends the cells from growing by delaying some proteins in hormone-positive breast cancer cells. It helps halt the cells from moving from G1 to S cell cycle phase in the division procedure. This reduces the growing of cancer.


How is Abemaciclib taken?

Abemaciclib is to be taken by mouth twice a day. Take this medication at around the same time each day. Carefully follow the instructions on your prescription label and ask your pharmacist or doctor to explain any part you do not understand. Take this medication exactly as directed. Do not take it more often or less than prescribed by your doctor.

If you experience certain side effects, your doctor may reduce your dose temporarily or permanently stop your treatment. This depends on how well the medication works for you and some certain side effects that you may experience. Make sure that you tell your doctor how you are feeling during your treatment with Abemaciclib. Also, avoid drinking grapefruit juice or eating grapefruit while using this medication unless your doctor says you may do it safely. Grapefruit may increase the chance of side effects with this drug. You can ask your doctor or pharmacist for more details.


What are the precautions in taking Abemaciclib?

  • Before taking this medication, inform first your doctor if you have any other medications (vitamins or herbal supplements).
  • While taking Abemaciclib, do not receive any vaccination or immunization without the approval of your doctor.
  • Consult your doctor if you are pregnant or planning to get pregnant. Abemaciclib may be unsafe for the fetus.
  • Maintain a healthy lifestyle and be sure to get an exact rest.
  • Do not share this medication with others who have the same conditions as yours.
  • Do not drive or do any activity that needs your alertness. This medicine may make you feel dizzy. Do certain activities if you know how this medicine will affect you.
  • Consult also your doctor if you are breastfeeding before taking this medicine. This drug may not be safe during breastfeeding.
  • This drug can make you more likely to get an infection. For this reason, avoid contact with people who have infections that might spread to other people.
  • Keep this medicine at a dry and clean place. Keep away from the reach of children.

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